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KOMBIGLYZE XR is proven to lower A1C levels

For patients whose blood sugar was not controlled enough by diet and exercise, KOMBIGLYZE XR was proven to lower A1C levels.

One very important goal in managing type 2 diabetes is lowering your A1C level to a number agreed upon by you and your healthcare provider.

The combination of saxagliptin and metformin hydrochloride, the two medicines that make up KOMBIGLYZE XR, has been tested in multiple clinical studies in thousands of adult patients with type 2 diabetes. In all of these studies, KOMBIGLYZE XR, in addition to diet and exercise, has been shown to lower A1C levels.

These results are the average responses from the total population in these studies. Your personal results may vary.

Your healthcare provider will determine if KOMBIGLYZE XR could give you the kickstart you need to reach your A1C goals.

24-Week clinical study

A 24-week clinical study involved 1,306 adult type 2 diabetes patients whose blood sugar was not controlled enough by diet and exercise. Of these patients, 643 were given saxagliptin plus metformin immediate release (IR), 335 were given saxagliptin plus placebo, and 328 were given a placebo plus metformin IR.

The patients started the study with an A1C of 9.4% to 9.6%, on average.

After 24 weeks, results showed significant A1C reduction; 60% of patients reached an A1C goal of less than 7%.**Your results may vary.

Serious side effects can happen in people who take KOMBIGLYZE XR, including inflammation of the pancreas (pancreatitis), which may be severe and lead to death.

Before taking KOMBIGLYZE XR, tell your doctor if you ever had pancreatitis, gallstones, history of alcoholism, or high triglyceride levels.

Stop taking KOMBIGLYZE XR and contact your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

Save with a $0 co-pay offer

You may be able to get KOMBIGLYZE XR for as low as $0 a month for as long as your doctor prescribes it.*


*Subject to eligibility. Restrictions apply. Not available for government-insured patients. Savings subject to monthly limit.


Download a KOMBIGLYZE XR brochure

Learn more about how KOMBIGLYZE XR can help kickstart your type 2 diabetes treatment plan.



Download the Doctor Discussion Guide

Talk to your healthcare provider to see if KOMBIGLYZE XR is right for you.



Join our patient support program

Get ongoing prescription coverage support, savings, and tips for managing type 2 diabetes.